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The first pass effect (also known as first-pass metabolism or presystemic metabolism) is a phenomenon of drug metabolism whereby the concentration of a drug is greatly reduced before it reaches the systemic circulation.
Valium belongs to a class of drugs called benzodiazepines, which work by increasing the effects of GABA, a neurotransmitter that moderates the activity of nerve signals in the brain. The Food and Drug Administration (FDA) approved diazepam in 1963 under the brand name Valium for the Roche drug company.
Valium is used to treat anxiety disorders, alcohol withdrawal symptoms, or muscle spasms. Learn about side effects, interactions and indications,
If Valium is discontinued abruptly after long term use, it may lead to seizures, insomnia, headaches, nausea, vomiting, lightheadedness, sweating, anxiety, and fatigue. Our Valium Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
First Pass Effect metabolism of orally administered drug in the liver before it reaches the systemic circulation significant first pass metabolism limits a drug’s bioavailability drugs with a high first-pass effect include: chlorpromazine, levodopa, morphine, propranolol, lidocaine, hydralazine, nortriptyline, and organic nitrates
First-pass effect or also known as first-pass metabolism or presystemic metabolism is when an administered drug enters the liver and undergoes extensive biotransformation and thus decreasing the concentration rapidly before it reaches its target.
first-pass metabolism the intestinal and hepatic degradation or alteration of a drug or substance taken by mouth, after absorption, removing some of the active ...
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