does lorazepam contain propylene glycol rating
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Propylene glycol is used as a solvent vehicle for several IV drugs, including lorazepam, diazepam, etomidate, phenytoin, nitroglycerin, hydralazine, esmolol, phenobarbital, trimethoprim-sulfamethoxazole, and chlordiazepoxide. Approximately 50% of a dose of propylene glycol is excreted unchanged by the kidneys.
Propylene glycol, also called propane-1,2-diol, is a synthetic organic compound with the chemical formula C3H8O2. It is a viscous colorless liquid which is nearly odorless but possesses a faintly sweet taste.
Lorazepam Intensol contains polyethylene glycol and propylene glycol. Lorazepam, an antianxiety agent, has the chemical formula, 2H-1,4-benzodiazepin-2-one, 7-chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-, (±)-: Lorazepam is a nearly white powder almost insoluble in water.
Propylene glycol is a diluent found in parenteral medications commonly used in clinical practice such as intravenous (IV) diazepam (Valium), lorazepam (Ativan), phenobarbital, phenytoin (Dilantin), and nitroglycerin.
Each mL of ATIVAN ® INJECTION contains 4 mg lorazepam, compounded with 80% propylene glycol, 18% polyethylene glycol and 2% benzyl alcohol.
Lorazepam is a nearly white powder almost insoluble in water. Each mL of sterile injection contains either 2.0 or 4.0 mg of lorazepam, 0.18 mL polyethylene glycol 400 in propylene glycol with 2.0% benzyl alcohol as preservative.
Propylene glycol is a solvent ... toxicity in a patient receiving intravenous diazepam for the ... Glycol Toxicity Associated with Lorazepam Infusion in ...
Propylene glycol is a common vehicle for many drugs, including topical silver sulfadiazine and intravenous preparations of nitroglycerin, diazepam, lorazepam, phenytoin, etomidate, and trimethoprim-sulfamethoxazole, among others. Although it is considered relatively safe, multiple case reports have verified the association of propylene glycol with lactic acidosis.
Correspondence. Hyperosmolar Metabolic Acidosis and Intravenous Lorazepam. N Engl J Med 2002; 347:857-858 September 12, 2002 DOI: 10.1056/NEJM200209123471121
Wyeth–Ayerst Laboratories) contains 0.8 ml of propylene glycol.2 We . ... fight back ativan and propylene glycol toxicity present danger to.